研究業績

教室業績

 

 2022年

SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation.

Wakimizu T, Morikawa K, Fukumura K, Yuki T, Adachi T, Kurata Y, Miake J, Hisatome I, Tsuneto M, Shirayoshi Y.

Regen Ther.2022；21:239-249. doi: 10.1016/j.reth.2022.07.012. eCollection2022 Dec.

 

Dipeptidy1 peptidase 4 inhibitor improves insulin resistance in Japanese patients with type 2 diabetes: a single-arm study, a brief report. 

Okura T, Fujioka Y, Nakamura R, Ito Y, Kitao S, Anno M, Matsumoto K, Shoji K, Okura H, Matsuzawa K, Izawa S, Ueta E, Kato M, Imamura T, Taniguchi SI, Yamamoto K.

Diabetol Metab Syndr.2022；14(1):78. doi: 10.1186/s13098-022-00850-9. 

 

The sodium-glucose cotransporter 2 inhibitor ipragliflozin improves liver function and insulin resistance in Japanese patients with type 2 diabetes. 

Okura T, Fujioka Y, Nakamura R, Kitao S, Ito Y, Anno M, Matsumoto K, Shoji K, Matsuzawa K, Izawa S, Okura H, Ueta E, Kato M, Imamura T, Taniguchi SI, Yamamoto K.

Sci Rep.2022；12(1):1896. doi: 10.1038/s41598-022-05704-y. 

 

α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats. 

Horie H, HIsatome I, Kurata Y, Yamamoto Y, Notsu T, Adachi M, Li P, Kuwabara M, Sakaguchi T, Kinugasa Y, Miake J, Koba S, Tsuneto M, Shirayoshi Y, Ninomiya H, Ito S, Kitakaze M, Yamamoto K, Yoshikawa Y, Nishimura M.

Hypertens Res.2022；45(2):283-291. doi: 10.1038/s41440-021-00802-2. Epub 2021 Dec 1.  

  

Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated recptor-1 and protein kinase C. 

Okamura A, Miake J, Tomomori T, Takami A, Sawano T, Kato M, Ogura K, Tsujimoto D, Kawatani S, Agung KP, Motsu T, Hisatome I, Yamamoto K, Imamura T.

J Pharmacol Sci.2022；148(4):351-357. doi: 10.1016/j.jphs.2022. 02. 001. 

 

 

2021年

 

Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction. 

Watanabe M, Horie H, Kurata Y, Inoue Y, Motsu T, Wakimizu T, Adachi M, Yamamoto K, Morikawa K, Kuwabara M, Sakaguchi T, Morisaki T, Miake J, Mishimura M, Tsuneto M, Shirayoshi Y, Ito S, Kitakaze M, Ninomiya H, Yamamoto K, Hisatome I.

Circ J.2021；85(5):657-666. doi: 10.1253/circj.CJ-20-0877.Epub 2021 Mar 12. 

 

Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats. 

Tawa M, Nagata R, Sumi Y, Nakagawa K, Sawano T, Ohkita M, Masaki T, Matsumura Y.

PLoS One2021；16(4):e0249816. doi: 10.1371/journal.pone.0249816. eCollection 2021.

  

Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, in Dahl Salt-sensitive Hypertensive Rats. 

Rahman A, Sawamo T, Sen A, Hossain A, Jahan N, Kobara H, Masaki T, Kosaka S, Kitada K, Nakano D, Imamura T, Ohsaki H, Nishiyama A.

International Journal of Molecular Sciences2021；19;22(4):2069. doi: 10.3390/ijms22042069. 

 

Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia.

Hisatome I, Li P, Miake J, Taufiq F, Mahati E, Maharani N, Utami SB, Kuwabara M, Bahrudin U, Ninomiya H.

Circulation Journal2021；25;85(2):130-138. doi: 10.1253/circj.CJ-20-0406.

 

MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells.

Iwasaki H, Ichihara Y, Morino K, Lemecha M, Sugawara L, Sawano T, Miake J, Sakurai H, Nishi E, Maegawa H, Imamura T.

Scientific Reports2021；13;11(1):1161. doi: 10.1038/s41598-020-80742-y.  

 

 

 

2020年

 

Epstein-Barr Virus Reactivation-Induced Immunoglobulin Production: Significance on Autoimmunity.

Nagata K, Hayashi K.

Microorganisms2020；8(12):E1875. doi: 10.3390/microorganisms8121875.

 

Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock.

Otani N, Kurata Y, Maharani N, Kuwabara M, Ikeda N, Notsu T, Li P, Miake J, Yoshida A, Sakaguchi H, Higaki K, Nakasone N, Tsuneto M, Shirayoshi Y, Ouchi M, Ninomiya H, Yammoto K, Anzai N, Hisatome I.

Circulation Reports2020；2;2(8):425-432. doi: 10.1253/circrep.CR-20-0016.

 

A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins.

Miake J.

Yonago Acta Medica2020；13;63(3):146-153. doi: 10.33160/yam.2020.08.002.       

 

Novel inhibitory effects of dotinurad, a selective urate reabsorption inhibitor, on urate crystal-induced activation of NLRP3 inflammasomes in macrophages Vascular Failure.

Taufiq F, Li P, Kuwabara M, Kurata Y, Hamada T, Takami A, Miake J, Tsuneto M, Shirayoshi Y, Kimiyoshi I, Ninomiya H, Miyazaki S, Mizuta E, Ohtahara A, Sugihara S, Ogino K, Kato M, Yamamoto K, Yamamoto T and Hisatome I.

Vascular Failure2020；3(2):59-67. doi: 10.30548/vascfail.3.2_59.

 

Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes.

Okura T, Fujioka Y, Nakamura R, Anno M, Ito Y, Kitao S, Matsumoto K, Shoji K, Sumi K, Matsuzawa K, Izawa S, Okura H, Ueta E, Noma H, Kato M, Imamura T, Taniguchi S, Yamamoto K.

BMJ Open Diabetes Research ＆ Care2020；8(1):e001149. doi: 10.1136/bmjdrc-2019-001149. 

 

Pretreatment with cilnidipine attenuates hypoxia/reoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening.

Minato H, Hisatome I, Kurata Y, Notsu T, Nakasone N, Ninomiya H, Hamada T, Tomomori T, Okamura A, Miake J, Tsuneto M, Shirayoshi Y, Endo R, Otsuki A, Okada F and Inagaki Y.

Hypertension Research2020；43(5):380-388. doi: 10.1038/s41440-019-0391-7. 

 

 

2019年

 

Different Effects of Pulmonary Vein Isolation on Quality of Life Between Patients with Persistent and Paroxysmal Atrial Fibrillation.

Kato M, Miake J, Ogura K, Iitsuka K, Okamura A, Tomomori T, Tsujimoto D, Kato M, Yamamoto K.

International Heart Journal2019；60(6):1328-1333. doi: 10.1536/ihj.19-201.

 

Involvement of γ-Glutamyl Transpeptidase in Ischemia/Reperfusion-Induced Cardiac Dysfunction in Isolated Rat Hearts.

Takeshi Koyama, Akari Tsubota, Tatsuya Sawano, Masashi Tawa, Bunta Watanabe, Jun Hiratake, Keisuke Nakagawa, Yasuo Matsumura, Mamoru Ohkita

Biological and Pharmaceutical Bulletin.2019；42(11):1947-1952.  doi: 10.1248/bpb.b19-00434.  

 

Hyperuricemia as a Risk Factor for Atrial Fibrillation Due to Soluble and Crystalized Uric Acid.

Taufiq F, Li P, Miake J, Hisatome I.

Circulation Reports.2019；1(11):469-473. doi: 10.1253/circrep.CR-19-0088. 

 

β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction.

Adachi M, Watanabe M, Kurata Y, Inoue Y, Notsu T, Yamamoto K, Horie H, Tanno S, Morita M, Miake J, Hamada M, Nakasone N, Ninomiya H, Tsuneto M, Shirayoshi Y, Yoshida A, Mishimura M, Yamamoto K, Hisatome I.

Circulation Journal2019；83(11):2282-2291. doi: 10.1253/circj.CJ-19-0261. 

 

Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.

Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.

Science Advances2019；5(9):eaau7802.  doi: 10.1126/sciadv.aau7802. 

 

Uric Acid-Induced Enhancements of Kv1.5 protein Expression and Channel Activity via the Akt-HSF1-Hsp70 pathway in HL-1 Atrial Myocytes.

Taufiq F, Maharani N, Li P, Kurata Y, Ikeda N, Kuwabara M, Otani N, Miake J, Hasegawa A, Tsuneto M, Shirayoshi Y, Ninomiya H, Saitoh T, Nakai A, Yamamoto K, Hisatome I.

Circulation Journal2019；83(4):718-726.  doi: 10.1253/circj.CJ-18-1088.

 

Pre-ablation levels of brain natriuretic peptide are independently associated with the recurrence of atrial fibrillation after radiofrequency catheter ablation in patients eith nonvalvular atrial fibrillation.

Miake J, Kato M, Ogura K, Iitsuka K, Okamura A, Tomomoti T, Tsujimoto D, Kato M, Yamamoto K.

Heart and Vessels2019；34(3): 517–526.  doi: 10.1007/s00380-018-1267-5

 

Inhibitory effects of class I antiarrhythmic agents on Na⁺ and Ca²⁺ currents of human iPS cell-derived cardiomyocytes.

Yonemizu S, Masuda K, Kurata Y, Notsu T, Higashi Y, Fukumura K, Li P, Ninomiya H, Miake J, Tsuneto M, Shirayoshi Y, Hisatome I.

Regenerative Therapy2019；10:104-111.  doi: 10.1016/j.reth.2018.12.002.

 

 

2018年

 

Local Cyclical Compression Modulates Macrophage Function in situ and Alleviates Immobilization-Induced Muscle Atrophy.

Saitou K, Tokunaga M , Yoshino D, Sakitani N, Maekawa T, Ryu Y, Nagao M, Nakamoto H, Saito T, Kawanishi N, Suzuki K, Ogata T, Makuuchi M, Takashima A, Sawada K, Kawamura S, Nakazato K, Kouzaki K, Harada I, Ichihara Y, Sawada Y.

CLINICAL SCIENCE2018; 132(19):2147-2161.  doi: 10.1042/CS20180432. 

 

MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes.

Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, Sato D, Sekine O, Ugi S, Maegawa H.

Scientific Reports2018; 8(1):15096.  doi: 10.1038/s41598-018-33438-3. 

 

Rapid-Growing Right Atrial Myxoma 7 Months After Catheter Ablation Under Anticoagulation Therapy - Serial Echocardiography and Computed Tomography.

Haruki N, Onohara T, Tsujimoto D, Iitsuka K, Kinugasa Y, Kato M, Nishimura M, Yamamoto K.

Circulation Journal2018; 82(10):2682-2683.  doi: 10.1253/circj.CJ-18-0081. 

 

Pretreatment with an angiotensin II receptor blocker abolished ameliorating actions of adipose-derived stem cell sheets on cardiac dysfunction and remodeling after myocardial infarction.

Yamamoto K, Kurata Y, Inoue Y, Adachi M, Tsuneto M, Miake J, Ogino K, Ninomiya H, Yoshida A, Shirayoshi Y, Suyama Y, Yagi S, Nishimura M, Yamamoto K ,Hisatome I.

Regenerative Therapy2018; 9:79-88.  doi: 10.1016/j.reth.2018.08.005. 

 

Improved Glucose Metabolism by Eragrostis Tef Potentially Through Beige Adipocyte Formation and Attenuating Adipose Tissue Inflammation.

Lemecha M, Morino K, Seifu D, Imamura T, Nakagawa F, Nagata A, Okamato T, Sekine O, Ugi S, Maegawa　H.

PLoS One2018; 13(8):e0201661.  doi: 10.1371/journal.pone.0201661. 

 

Pretreatment with topiroxostat and irbesartan improve cardiac function after myocardial infarction of rats.

Tanno S, Sugihara S, Yamamoto K, Adachi M, Inoue Y, Otani N, Iituka K, Ogura K, Kato M, Miake J, Ogino K, Tsuneto M, Yoshida A, Shirayoshi Y, Kuwabara M, Yamamoto K, Ninomiya H, Hisatome I.

Vascular Failure2018;2(2):74-79. doi:https://doi.org/10.30548/vascfail.2.2_74

 

Body Mass Index ≥23 Is a Risk Factor for Insulin Resistance and Diabetes in Japanese People: A Brief Report.

Okura T, Nakamura R, Fujioka Y, Kawamoto-Kitao S, Ito Y, Matsumoto K, Shoji K, Sumi K, Matsuzawa K,　Izawa S, Ueta E, Kato M, Imamura T, Taniguchi S , Yamamoto K.

PLoS One2018; 13(7):e0201052.  doi: 10.1371/journal.pone.0201052. 

 

Stimulation of Nitric Oxide-Sensitive Soluble Guanylate Cyclase in Monocrotaline-Induced Pulmonary Hypertensive Rats.

Tawa M, Furukawa T, Tongu H, Sugihara M, Taguwa S, Yamanaka M, Yano Y, Matsumori H, Kitada R, Sawano T, Tanaka R, Ohkita M, Matsumura Y.

Life Sciences2018; ;203:203-209.  doi: 10.1016/j.lfs.2018.04.045. 

 

Coenzyme Q10 Suppresses Apoptosis of Mouse Pancreatic β-Cell Line MIN6.

Sumi K, Okura T, Fujioka, Kato K, Imamura T, Taniguchi S, Yamamoto K. 

Diabetology & Metabolic Syndrome2018; 10:47.  doi: 10.1186/s13098-018-0351-4. 

 

CPR-IR Is an Insulin Resistance Index That Is Minimally Affected by Hepatic Insulin clearance-A Preliminary Research.

Okura T, Nakamura R, Fujioka Y, Kawamoto-Kitao S, Ito Y, Matsumoto K, Shoji K, Sumi K, Matsuzawa K, Izawa S, Ueta E, Kato M, Imamura T, Taniguchi S, Yamamoto K.

PLoS One2018; 13(5):e0197663.  doi: 10.1371/journal.pone.0197663. 

 

個人業績

 

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